3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid
LDN-91946
CAS: 439946-22-2
Molecular Formula: C15H10N2O4S
3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid - Names and Identifiers
| Name | LDN-91946 |
| Synonyms | LDN-91946 3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid Thieno[2,3-b]pyridine-5-carboxylic acid, 3-amino-2-benzoyl-6,7-dihydro-6-oxo- |
| CAS | 439946-22-2 |
3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C15H10N2O4S |
| Molar Mass | 314.3159 |
| Density | 1.554±0.06 g/cm3(Predicted) |
| Melting Point | 327-329 °C(Solv: acetic acid (64-19-7)) |
| Boling Point | 714.0±60.0 °C(Predicted) |
| Appearance | Solid |
| pKa | 2.26±0.20(Predicted) |
| Storage Condition | 2-8°C，密封，干燥 |
| In vitro study | LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM. |
3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid - Reference Information
| biological activity | LDN-91946 is a potent non-competitive selective ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) the inhibitor, Ki app, was 2.8 μm. |
| Target | Ki app: 2.8 μm (UCH-L1) |
Last Update：2024-04-09 21:11:58
![3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid](http://res.chembk.com/assets/str/2d/4/43/439946-22-2.png)